Breast Cancer (BC)


Breast cancer is a malignant tumor originating from breast tissue: milk ducts (up to 85%) or lobules of glandular breast tissue (up to 15%).

Breast cancer is the most common type of cancer and the leading cause of cancer death in women.

During the lifetime, approximately one in twelfth women will experience breast cancer. If a woman dies from breast cancer, then it happens due to extensive metastasis.

Lobules — glands that produce breast milk. Cancer that starts here is called lobular cancer.

Ducts — small channels that start into the lobules and carry milk to the nipple. This is the most common place where breast cancer starts. Cancer that starts here is called ductal cancer.

Nipple — an opening in the skin of the breast where the ducts join. The nipple is surrounded by a slightly darker thick skin called the areola. A rare type of breast cancer can start in the nipple and is called Paget’s disease.

Stroma — connective tissue (stroma) and fatty tissue surround the ducts and lobules and help hold them in place. A rare type of breast cancer, called a phyllode tumor, can start in the stroma.

Lymph nodes — blood and lymph nodes are also found in each mammary gland. Angiosarcoma is a rare type of breast cancer that can start in the lining of these vessels.

Most breast tumors are benign and do not have the ability to spread outside the gland.

Other less common types of exocrine cancer include:

  • adenosquamous carcinoma,
  • squamous cell carcinoma,
  • signet ring cell carcinoma,
  • undifferentiated carcinoma,
  • undifferentiated giant cell type carcinoma.
Oncotarget. 2017 Jul 25; 8(30): 50252–50272

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