Breast Cancer (BC)

Diagnostics

The diagnosis is established on the basis of anamnestic, laboratory data and the results of an instrumental examination.

Check-up plan:

Examination, palpation of the mammary glands and regional lymph nodes, medical history, family history
Clinical blood and urine analysis
Biochemical blood test with assessment of liver and kidney function, determination of glucose, calcium levels
Hemostasis system diagnostics
Bilateral mammography + ultrasound of the mammary glands and regional lymph nodes
MRI, if age is up to 30 years, presence of BRCA1 / 2 mutations, high radiological density of mammary glands, presence of mammary gland implants, lobular carcinoma in situ
X-ray / CT / MRI of the chest
Ultrasound / CT / MRI of the abdominal cavity and small pelvis
Biopsy of the tumor with pathomorphological examination of the tumor tissue, determination of the histological variant of the tumor and the grade of malignancy; determination of ER, PR, HER2 and Ki67 in tumor tissue
FSH, serum estradiol to assess ovarian function
Determination of BRCA1 / 2 germinal mutations by NGS (or first by PCR for the most common mutations)

Статьи по теме Breast Cancer (BC)

Breast Cancer (BC)

Definition

Breast cancer is a malignant tumor originating from breast tissue: milk ducts (up to 85%) or lobules of glandular breast tissue (up to 15%)

Breast Cancer (BC)

Staging is based on the TNM classification. The most recent American Joint Committee on Cancer (AJCC) system, in effect since January 2018, has both a clinical and pathological breast cancer staging system

Breast Cancer (BC)

Symptoms

Most often, breast cancer appears as a painless «ball» (bump) or lump in the chest. Moreover, if the mass is hard and with jagged edges, then the likelihood of cancer is higher